August 22, 2026 6 min read
If you often feel cold during chemotherapy, immunotherapy, IV infusions, or other long treatment sessions, you're not alone. Infusion centers and treatment rooms can feel chilly, and sitting still for an extended period can make it even harder to stay comfortable.
The good news is that a little preparation can make a big difference. From choosing the right clothing to bringing warm accessories, here are practical ways to help you stay warm and comfortable during infusions without making it difficult for your care team to access your port or IV.
There are several reasons you may feel colder than usual during treatment. Infusion centers may keep room temperatures cool, and sitting in one place for an extended period naturally makes it harder to stay warm.
Some cancer treatments can also cause flu-like symptoms, including chills. The National Cancer Institute explains flu-like symptoms that can occur during cancer treatment, including when patients should contact their healthcare team.
If feeling unusually cold is new, severe, or accompanied by symptoms such as fever or chills, tell your healthcare team rather than assuming it's simply the temperature of the room.
Layering is one of the easiest ways to prepare for changing temperatures during an infusion.
Start with a soft, breathable base layer and add a cardigan, zip-front sweatshirt, vest, or other lightweight layer that can be removed easily.
Avoid creating too many layers around the area your nurse needs to access. Your clothing should help keep you warm without interfering with your chest port, PICC line, IV, or other treatment access point.
One of the challenges of dressing warmly for treatment is that nurses still need access to your chest, arm, or other treatment site.
Traditional sweaters and long-sleeve tops may need to be pulled up, stretched, partially removed, or left open during treatment.
Port access clothing can provide a more comfortable alternative.
For example, a chest port access shirt can allow access near the collarbone while helping the rest of your upper body remain covered. For treatments involving an arm access point, strategically placed snap openings along the sleeves can provide access without requiring you to remove the entire shirt.
The National Cancer Institute explains that IV chemotherapy may be administered through a needle, catheter, or implanted port. A port is generally placed under the skin and can be used to administer chemotherapy and other treatments.
This can be particularly helpful during long appointments when warmth, privacy, and comfort matter.
Even if your infusion center provides blankets, consider bringing one you already know you love.
A lightweight fleece or soft throw can make the treatment chair feel more comfortable and familiar.
Choose something warm but not excessively bulky, especially if you need to carry several items to your appointment.
Cold feet can make your entire body feel chilly.
Wear comfortable socks and closed-toe shoes on treatment days. Soft, non-restrictive socks can be particularly comfortable when you'll be sitting for several hours.
Some patients also like to bring an extra pair of warm socks in their treatment bag.
A soft scarf, wrap, beanie, or head covering can provide another layer of warmth without adding bulk around your arms.
If you're experiencing hair loss or scalp sensitivity during cancer treatment, choose fabrics that feel gentle against your skin.
Be careful with scarves or garments around the neck and upper chest if your healthcare team needs access to a chest port.
A soft scarf, wrap, beanie, or head covering can provide another layer of warmth without adding bulk around your arms.
If you're experiencing hair loss or scalp sensitivity during cancer treatment, choose fabrics that feel gentle against your skin.
Be careful with scarves or garments around the neck and upper chest if your healthcare team needs access to a chest port.
A warm drink can feel especially comforting during a long treatment session.
Depending on your treatment plan and any dietary or fluid restrictions, your healthcare team may allow options such as warm water or tea.
Always follow your healthcare team's recommendations regarding fluids, caffeine, potassium, phosphorus, sodium, sugar, or other dietary restrictions.
However, fluid recommendations aren't the same for everyone. This is particularly important for people receiving dialysis. TheNational Kidney Foundation explains that people receiving hemodialysis may need individualized fluid and dietary restrictions.
Having a small bag ready for treatment can make appointments less stressful.
Consider packing:
A warm blanket
Comfortable socks
A soft scarf or wrap
Lip balm
Headphones
Phone charger
Book, tablet, or magazine
Water or an approved beverage
A small snack, if permitted by your healthcare team
Keeping these essentials together means you won't have to remember everything before each appointment.

Treatment can sometimes make skin feel more sensitive than usual.
Look for clothing that is soft, breathable, and comfortable for extended periods of sitting. Avoid anything excessively tight, scratchy, or restrictive around your treatment access area.
Comfort isn't only about temperature. The way clothing feels against your body can make a significant difference during a long treatment day.
Medical treatment can sometimes make everyday routines feel very clinical.
What you wear may seem like a small detail, but being able to dress in clothing that feels familiar and reflects your personal style can help treatment days feel a little more normal.
You shouldn't have to choose between medical access and feeling comfortable, covered, and like yourself.
The ideal infusion outfit depends on where your healthcare team needs access.
Choose a shirt that allows easy access around the upper chest or collarbone while keeping the rest of your body covered.
The National Cancer Institute describes a port as a device placed under the skin that can be used to draw blood and administer treatments, including chemotherapy and IV fluids.
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Choose a top with sleeves that can open or move easily around the treatment area without requiring you to undress.
Shop Women's Arm Port Access Shirts
Prioritize soft fabrics, warmth, relaxed fits, easy medical access, comfortable socks, and removable layers.
When in doubt, ask your nurse or infusion center what type of access will be needed before your appointment.
Why are infusion centers so cold?
Healthcare facilities may maintain cooler indoor temperatures, and patients who remain seated for long periods can become uncomfortable even when the room temperature seems reasonable to others.
Can I bring my own blanket to chemotherapy or an infusion?
Many infusion centers allow patients to bring personal comfort items such as blankets, but policies can vary. Ask your treatment center if you're unsure.
What is the best clothing to wear for chemotherapy?
Choose soft, comfortable clothing that provides easy access to the area being used for treatment. If chemotherapy is administered through a chest port, clothing designed with chest port access can help you stay covered while allowing your nurse to reach the port.
For more information about how chemotherapy is administered, visit theNational Cancer Institute's guide to chemotherapy.
What should I wear if I have a PICC line?
A loose-fitting top or a shirt designed with arm openings can make it easier for your healthcare team to access a PICC line while helping you remain comfortable and covered.
How can I stay warm without covering my port?
Use layers that leave the treatment area accessible, combined with warm socks, a blanket, and clothing specifically designed to open around your chest or arm access point.
Comfort Can Make Treatment Days a Little Easier
You can't control everything about a chemotherapy, infusion, or dialysis appointment, but you can prepare for your comfort.
Dress in layers, keep your feet warm, bring a favorite blanket, and choose clothing that gives your healthcare team easy access without requiring you to unnecessarily expose or remove clothing.
At Wear 2 Conquer, our treatment clothing was inspired by a family's experience with long-term medical treatments. Our chest and arm port access shirts are thoughtfully designed to help women stay warm, comfortable, covered, and confident while giving healthcare professionals convenient access during treatment.
Because treatment clothing should work for your care — and still feel like you.
Explore Wear 2 Conquer Chest Port and Arm Port Access Shirts
This article is intended for general educational purposes and is not medical advice. Treatment experiences and medical needs vary. Always follow the recommendations of your physician, nurse, dialysis team, or infusion care team.